Toxicological Risk Assessments (TRA)

Toxicological Risk Assessments (TRA)

Toxicological risk assessments (TRA) is a hazardous substance control that identifies dangerous chemical substances in consumer products, which is of great concern to consumers, retailers, and law makers. In addition to posing serious health risks to the general public, these chemicals are toxic to the environment.

The principle of of toxicological risk assessment is based on evaluating the hazard or inherent toxicity of the individual chemical ingredient, such as acute toxicity, repeat dose toxicity, skin sensitivity, skin/eye irritation, aspiration hazard, reproductive toxicity, or carcinogenicity, in relation to the potential consumer exposure to the chemical. Meanwhile, it also checks whether the product compiles with the relevant laws and regulations of different countries. 

Eurofins | MTS board-certified team of toxicologists with extensive experience in the field of toxicological risk assessment offers its clients a wide range of services related to risk and hazard assessment in accordance with relevant laws and regulations including: 

Standards that Requires TRA by Countries

United States:

  • Federal Hazardous Substance Act

  • 16 CFR 1500 Hazardous Substances and Articles


  • Hazardous Product Act RSC 1985

  • Consumer Chemical Container Regulations 2001

  • Toy Regulations (SOR 2011-17)

  • Canada Consumer Product Safety Act SC 2011


  • Directive 1994/45/EC

  • Directive 67/548/EEC: “DSD”

  • Directive 2006/121/EC

  • EN 71/9 Directive 1999/45/EC:  Dangerous Preparation Directive. “Toy”

  • Regulation (EC) No 1907/2006: REACH

  • Regulation (EC) No 1272/2008 on classification, labeling, and packaging (CLP) of substances and mixtures.